154 replies to this topic

[szedlisa]

We had problems with a hacked server but all is okay now.
There should be no troubke getting into the CA WEBsite now.

Sorry about the delays !

Lisa

[Heidi]

CEREBELLAR ABIOTROPHY results for Bint Safiera(CBA7521):

N/N - Normal: horse does not possess the mutation associated with CA

CEREBELLAR ABIOTROPHY results for NADEERAH ALIAH(CBA7522):

N/N - Normal: horse does not possess the mutation associated with CA

CEREBELLAR ABIOTROPHY results for SHAMS EL BINA(CBA7523):

N/N - Normal: horse does not possess the mutation associated with CA

[szedlisa]

Cross posting so my apologies if you have already seen this announcement:

GREAT NEWS:

The laboratory of the Netherlands @ Dr. Van Haeringen Laboratorium (VGL)is now offerring in-house testing with the new CA test at very reasonable prices:

€42.50 = US$59.08, €40.00 = US$55.61, €15.00 = US$20.85, €70.00 = US$97.32. (current exchange rate 12Mar2011)

- CA ONLY @ 42.50€ (single samples)
- SCID ONLY @ 40.00€ (single samples)
- LFS ONLY @ 40.00€ (single samples)
- Optional ADD DNA-Profile @ + 15.00€ (single samples)

- COMBO: CA + SCID + LFS + DNA-Profile @70.00€


Click HERE for the information flyer
The test can be done on hair roots or blood. Please send in the material and a sample submission form, which you can print out from our website. ("Genetic properties') If you cannot print them please let us know and we will send some sample submission forms by post. You do not need an import permit within the European Union.

Link/info: http://www.vhlgeneti....php?dsrt=paard
Dr. Van Haeringen Laboratorium BV
P.O. Box 408
6700 AK Wageningen
Netherlands
Tel +31 317 416 402
Fax +31 317 426 117
http://www.vhlgeneti...dex.php?lang=uk
info@vhlgenetics.com   

--------------------------------------------------------------------------------
The price of under $100.00 for a combined test of Parentage identification for Registration (DNA-Profile) plus CA, LFS AND SCID is an eye opener. It certainly shows how a registry and a corresponding certified laboratory can work together to reduce the costs for todays horse breeders and owners!

Congratulations to the Dutch and their AVS. !!!!!!!!!!
:bigemo_harabe_net-122:  :bigemo_harabe_net-122:  :bigemo_harabe_net-122:

Lisa

[An American Breeder]

szedlisa, on 12 March 2011 - 04:24 PM, said:

Cross posting so my apologies if you have already seen this announcement:

GREAT NEWS:

The laboratory of the Netherlands @ Dr. Van Haeringen Laboratorium (VGL)is now offerring in-house testing with the new CA test at very reasonable prices:

€42.50 = US$59.08, €40.00 = US$55.61, €15.00 = US$20.85, €70.00 = US$97.32. (current exchange rate 12Mar2011)

- CA ONLY @ 42.50€ (single samples)
- SCID ONLY @ 40.00€ (single samples)
- LFS ONLY @ 40.00€ (single samples)
- Optional ADD DNA-Profile @ + 15.00€ (single samples)

- COMBO: CA + SCID + LFS + DNA-Profile @70.00€


Click HERE for the information flyer
The test can be done on hair roots or blood. Please send in the material and a sample submission form, which you can print out from our website. ("Genetic properties') If you cannot print them please let us know and we will send some sample submission forms by post. You do not need an import permit within the European Union.

Link/info: http://www.vhlgeneti....php?dsrt=paard
Dr. Van Haeringen Laboratorium BV
P.O. Box 408
6700 AK Wageningen
Netherlands
Tel +31 317 416 402
Fax +31 317 426 117
http://www.vhlgeneti...dex.php?lang=uk
info@vhlgenetics.com   

--------------------------------------------------------------------------------
The price of under $100.00 for a combined test of Parentage identification for Registration (DNA-Profile) plus CA, LFS AND SCID is an eye opener. It certainly shows how a registry and a corresponding certified laboratory can work together to reduce the costs for todays horse breeders and owners!

Congratulations to the Dutch and their AVS. !!!!!!!!!!
:bigemo_harabe_net-122:  :bigemo_harabe_net-122:  :bigemo_harabe_net-122:

Lisa

In the poll and discussion in the DISCUSSION section of this forum the question has been asked?  How will the Netherlands tests be treated in regard to export rules -- ie an American horse is sold overseas will the Netherland tests be accepted overseas as the American tests are?

[szedlisa]

An American Breeder, on 14 March 2011 - 09:41 PM, said:

In the poll and discussion in the DISCUSSION section of this forum the question has been asked?  How will the Netherlands tests be treated in regard to export rules -- ie an American horse is sold overseas will the Netherland tests be accepted overseas as the American tests are?

I do not see why not.
The Van Haeringen Laboratory has been working in unison with the VGL lab at UC Davis since day one and are now using the same causative mutation DNA testing as used by Dr.Cecilia Penedo at the VGL lab , UC Davis. The european registry may require that a copy of the CA or SCID or LFS test certificate be sent directly from the test lab to the european registry. This is done in order to avoid any human error on horse identification and any possible fiddling on the certificates.

Lisa

[szedlisa]

FLASH NEWS:


Dr. Cecilia Penedo at the VGL lab of UC Davis is now doinng the CA tests at $40.00 per sample.

As they continue to do their research on CA as to the ´whys ´of the different levels of clinical signs and the different times they are expressed, please continue to send your samples to them.  This aides in their research and we all will benefit.

Lisa

[szedlisa]

The following is our latest news item on Hannover:
WHERE TO TEST FOR CA:
http://www.cerebella...id=55&Itemid=59

Dr. Distl is now using the test identified at the VGL lab, UC Davis, for his testing at Hanover University. They are retesting all N/CA and CA/CA results tested by them free of charge. Horse owners will be advised if any status changes. Testing with the new improved CA-Test commenced the beginning of March 2011.


http://www3.tiho-han.../mol_gen/ca.htm

[M Huprich]

I'd read somewhere that horse horse tested for clear in Europe had a ca affected foal.  Is Hanover retesting all the ca clear ones too?

[szedlisa]

Yes and this has been completed by now.

Any new test results which have been posted on the CA Public List have been updated.

Lisa

[diane]

Cerebellar Abiotrophy: Not Just for Arabians? by: Erica Larson, News Editor May 10 2011.

To my mind, this was just a matter of time.  To suggest it jumped the breed barrier (per the start of the article) is a furphy!  Breeds with Arabian lineage suggest that the inheritance factor is there.  Therefore some breeds with Arabian lineage are going to be predisposed as Penedo asserts further in the article rather than jumping any barriers.  Breeders are just breeding with a focus <sigh>  

The possible fall-out from this on the Arabian in general is something that the Societies as well as Breeders, worldwide, will need to anticipate and promote against or to avoid ie promote positive as well as show that genetic testing is being undertaken.

[szedlisa]

Several new research papers have been published on CA:

http://onlinelibrary...0166.x/abstract
http://onlinelibrary...0166.x/abstract

Cerebellar abiotrophy in a 6-year-old Arabian mare with delayed diagnosis. Equine Veterinary Education Volume 23, Issue 3, pages 130–134, March 2011
Foley, A., Grady, J., Almes, K., Patton, K. and Davis, E. (2011), Cerebellar abiotrophy in a 6-year-old Arabian mare. Equine Veterinary Education, 23: 130–134. doi: 10.1111/j.2042-3292.2010.00166.x


http://onlinelibrary...0194.x/abstract
http://onlinelibrary...0194.x/abstract

. Equine Veterinary Education Volume 23, Issue 3, pages 135–137, March 2011
Johnson, A. L. (2011), Equine cerebellar abiotrophy: Searching the genome for an explanation. Equine Veterinary Education, 23: 135–137. doi: 10.1111/j.2042-3292.2010.00194.x (No Abstract available)

AND a Very Important new research paper published about CA in Non-Arabian Horses.

All three have been posted and/or linked to at the CA Website
http://www.cerebella...-news&Itemid=28
http://www.cerebella...-news&Itemid=28

From our first postings back in 2005 and en masse in 2007, we have been saying NOT to cross breed with CA Carriers and NEVER to breed with CA Affecteds at any time.

Cross breeding with a known CA Carrier into another breed whether it be semi related as in Anglo-Arabs or Shagya Arabers or non related such as quarter horses and their derivitives is frankly a sacriledge in my opinion. The arabian breed has enough problems in confronting CA within its own breed; it does not nor should not be spreading it into other breeds as well.  If owners plan to breed their CA Carrier horses then keep it within the arabian breed. Please.

And it makes little difference if the disorder is introduced years and years ago. Look at the Bashkir Curlies. It has been ascertained that a purebred arabian stallion which was a CA Carrier was used in the 60s. Easy enough to find he is clearly named on the Bashkir Curlie website as a Foundation stallion and was used extensively. His pedigree is certainly familar to most of us: Nevada Red

With the above research papers, I hope it is becoming clearer that YES, there can be a delayed expression of the clinical signs for CA and that YES, we are going to find this disorder in other breeds if we continue to introduce arabian blood without testing.  For example, the anglo arab is an extremely popular sport horse in many countries. Who is going to test all stock when they breed onwards unless they have been throughly warned about CA?

It is mind boggling as to what could happen.

Lisa

[Demelza]

szedlisa, on 21 May 2011 - 01:54 PM, said:

Several new research papers have been published on CA:

http://onlinelibrary...0166.x/abstract
http://onlinelibrary...0166.x/abstract

Cerebellar abiotrophy in a 6-year-old Arabian mare with delayed diagnosis. Equine Veterinary Education Volume 23, Issue 3, pages 130–134, March 2011
Foley, A., Grady, J., Almes, K., Patton, K. and Davis, E. (2011), Cerebellar abiotrophy in a 6-year-old Arabian mare. Equine Veterinary Education, 23: 130–134. doi: 10.1111/j.2042-3292.2010.00166.x


http://onlinelibrary...0194.x/abstract
http://onlinelibrary...0194.x/abstract

. Equine Veterinary Education Volume 23, Issue 3, pages 135–137, March 2011
Johnson, A. L. (2011), Equine cerebellar abiotrophy: Searching the genome for an explanation. Equine Veterinary Education, 23: 135–137. doi: 10.1111/j.2042-3292.2010.00194.x (No Abstract available)

AND a Very Important new research paper published about CA in Non-Arabian Horses.

All three have been posted and/or linked to at the CA Website
http://www.cerebella...-news&Itemid=28
http://www.cerebella...-news&Itemid=28

From our first postings back in 2005 and en masse in 2007, we have been saying NOT to cross breed with CA Carriers and NEVER to breed with CA Affecteds at any time.

Cross breeding with a known CA Carrier into another breed whether it be semi related as in Anglo-Arabs or Shagya Arabers or non related such as quarter horses and their derivitives is frankly a sacriledge in my opinion. The arabian breed has enough problems in confronting CA within its own breed; it does not nor should not be spreading it into other breeds as well.  If owners plan to breed their CA Carrier horses then keep it within the arabian breed. Please.

And it makes little difference if the disorder is introduced years and years ago. Look at the Bashkir Curlies. It has been ascertained that a purebred arabian stallion which was a CA Carrier was used in the 60s. Easy enough to find he is clearly named on the Bashkir Curlie website as a Foundation stallion and was used extensively. His pedigree is certainly familar to most of us: Nevada Red

With the above research papers, I hope it is becoming clearer that YES, there can be a delayed expression of the clinical signs for CA and that YES, we are going to find this disorder in other breeds if we continue to introduce arabian blood without testing.  For example, the anglo arab is an extremely popular sport horse in many countries. Who is going to test all stock when they breed onwards unless they have been throughly warned about CA?

It is mind boggling as to what could happen.

Lisa

Thanks for this Lisa. Makes me wonder if we not only have a moral obligation but a legal obligation to either test all breeding stock or educate other breed organisations to test (not just CA but also SCID and LFS) any horses with Arabian blood.

[szedlisa]

Demelza, on 23 May 2011 - 12:34 AM, said:

Thanks for this Lisa. Makes me wonder if we not only have a moral obligation but a legal obligation to either test all breeding stock or educate other breed organisations to test (not just CA but also SCID and LFS) any horses with Arabian blood.

Demelza,

I have personally been working with the Shagya Araber group registry ( both in the USA and Germany) in hopes that they will approve testing. Some Shagyas have already been tested by UC Davis. The clear ones have been posted but there have been carriers and there is an existing history of several affecteds.

What really concerns me is the Anglo-Arab and the "Half-Arabian part breds".  Both are huge in numbers.  At least in some european countries,, pre-testing of any arabians to be used/introduced, has become a prerequisite. The European Sport Horse could become a disaster otherwise. In the USA, without any form of control, we could really be creating a situation which will have no cure.

Lisa

[Demelza]

An interesting study... has anyone read it? I can't find an online source, but it is cited in "Frequency of the severe combined immunodeficiency disease gene among horses in Morocco" which is available online for a fee.


Title: Absence of the severe combined immunodeficiency disease gene among Arabian horses in Poland
Authors: Terry R.R., Cholewinski G., Cothran E.G.
Source: Journal of Applied Genetics
year: 1999, vol: 40, number: 1, pages: 39-41

Publication order reference:
E.G. Cothran, 101 Animal Pathology, Lexington, KY 40502, U.S.A. E-mail: gcothran@pop.uky.edu.
Abstract: Severe combined immunodeficiency disease (SCID) is an autosomal recessive disease occurring in Arabian horses. A recent discovery of a five base pair deletion in the gene encoding DNA-PK catalytic subunit has led to a PCR based test to screen for carriers of this disease. It has been suggested that the origin of this mutation arose from a stallion that originated in Poland. For this reason the occurrence of the SCID allele was tested on a representative sample of Polish horses. None of the 271 horses tested were carriers for this mutated allele.

[szedlisa]

http://www.cerebella...id=54&Itemid=64

The CA Public Website is now under the direction of a professional webmaster and has been updated and both lists consoladated and made into One Alphabetisized List.

So much easier to track down horses and especially those that have been outted but as yet not publically disclosed as carriers.

Lisa