46 replies to this topic

[Heidi]

Cornell University has developed a direct DNA test for LFS that will be commercially available in the near future.

[Suellen Taylor]

That is such good news...now for JE and GPT..hopefully in the near future.

I think there are probably more JE foals than the others, but any test is a good test!

[Juniper]

so sooo happy!
The progress is so fast, pretty soon we won't be blind anymore.

[chiron]

  

Is there any chance that those of us who were first in line to supply samples might get a little discount???    That sounds so petty I know, but I'm soooooo broke right now but really really anxious for results on a couple of the horses here..  

Big Kudos to Cornell & all who helped support they're research.  Job well done.

Next step JES & GPT    

[dakhilah]

Hi All,

That is really GREAT!!!!!!!


Greetings sas.

[Trish aka JMO]

That is just the most wonderful news and all those who provided samples I    you for making this happen.

I'm amazed with the small steps that we started with  & just how far we come.....

So of 5 genetic problems we know about we have 3 tests available and 2 to go....

[Melissa]

This is so great to read!!!

[Juniper]

Can somebody post the link to the official release in this section?
I would like to share with others but don't want to go through 100ds of posts.
I know I have seen one somewhere but where?

[Juniper]

just read this that a friend found.
LFS test - S Africa

Quote

Lavender Foal Syndrome Test in Arabian horses is now available!

The Onderstepoort Veterinary Genetics Laboratory has recently found the mutation responsible for the genetic condition known as Lavender Foal Syndrome (LFS) in Arabian horses and has developed a DNA based test for this condition. The mode of inheritance of LFS and SCID (Severe Combined Immunodeficiency Disease) is similar, both are autosomal recessive and test results indicate whether an animal has 2 defective alleles (affected), one defective allele (carrier) or 2 normal alleles (clear). The affected animal has a pale blue / lavender coat colour and severe neurological deficits that are incompatible with life and will result in death within hours to a maximum of a few days. The clear and carrier animals are completely normal. Similar to SCID, an affected animal can only be produced when 2 carriers are bred to each other, but no affected animals will be produced when a clear and carrier are bred to each other. A test and selective breeding strategy is, therefore, again recommended for LFS, similar to that done with SCID that resulted in a decrease of SCID carrier prevalence in the South African Arabian horse population from 8.3% to 5.2% since 2004.

The discovery of the LFS mutation and development of the genetic test is a significant scientific finding and will make a valuable contribution to the knowledge of the genetics of the horse. The discovery has also highlighted the value of the close cooperation between our laboratory at the Faculty of Veterinary Science and the Arabian horse breeding community. Without the support and samples supplied by breeders locally this achievement would not be possible. Not only is our Arabian breeding community unique in its support of scientific study, particularly in terms of genetics but also in the application of genetic disease test results. The open test and selective breeding strategy used to reduce the prevalence of SCID is also an indication of the local Arabian breeder’s commitment to removing unwanted traits from our stock while maintaining the favourable genetics.

Two independent tests?

[phanilah]

The official release re: the Cornell test will come when the embargo is released on the scientific manuscript pending publication and the licensing details are finalized with the lab(s) who will commerically offer the test; as Cornell is not set up to commerically run the test.

The South African test is a separate test, offered by a lab in South Africa based on work they have done.  I haven't seen any published work regarding this test and am not sure if they have anything submitted for publication or not.

Beth

[Meralee]

I sent in samples for the reserch and I am happy to report that BOTH Golden Desra and Jubilee Princess are NON CARRIERS!!!
I downloaded the info to get Jub tested for CA,I hope to breed her next year. Her Dad is SCIDS free so unless I fall in love with a carrier will not be testing her for that. Mer  Here is the "princess"

Attached Files

•  Jubilee_7_09.jpg   602.37K   2 downloads

[JRS Gentle Hills]

Do they have a company in the US doing this test?

[Juniper]

JRS Gentle Hills, on Jun 16 2010, 09:22 AM, said:

Do they have a company in the US doing this test?

It should be available very soon (a month?) from Cornell if I understood well!

[JRS Gentle Hills]

Juniper, on Jun 16 2010, 12:04 PM, said:

It should be available very soon (a month?) from Cornell if I understood well!

  Oh, ok.  Thanks!

[Seglavi]

Where the heck is the test?

[DJ Sheldon]

Good question.  It was my understanding it was going to "go to market" last week.  Still waiting......

[firepanther]

I had never heard of this until I read up on it at the Institute for the Desert Arabian Horse! I'm so glad I'm doing lots of research
From reading the article it sounds like it should be available soon
"Cornell University, where the research was conducted, is expected to announce in the next few weeks whether they will offer the test or if it will be licensed to a commercial lab."
Not sure exactly when that phrase was published, but hopefully it will be available shortly!

[phanilah]

They are going through the final administrative hoops, so everyday I check my email for the update.

Beth

[diane]

phanilah, on Jul 27 2010, 06:56 PM, said:

They are going through the final administrative hoops, so everyday I check my email for the update.

Beth

Thanks, Beth.  Looking forward to good news  

[V6297]

It's up:

http://ahdc.vet.corn...p?testcode=LFSG